[Cost-effectiveness analysis of peginterferon beta-1a in Italian relapsing remitting multiple sclerosis management]
DOI:
https://doi.org/10.7175/fe.v17i2S.1230Keywords:
Cost-effectiveness, Peginterferon beta-1a, Multiple SclerosisAbstract
BACKGROUND: Peginterferon beta-1a is indicated in adult patients for the treatment of relapsing remitting multiple sclerosis (RRMS). The efficacy and safety of peginterferon beta-1a was demonstrated in the placebo-controlled ADVANCE trial.
OBJECTIVE: The objective of this study was to assess the cost-effectiveness of peginterferon beta-1a as compared with injectable first-line treatments for RRMS in Italy.
METHODS: The cost-effectiveness analysis was developed through a Markov model with lifetime simulation in the perspective of the Italian National Healthcare Service (NHS). It was added an alternative scenario to take into account the Italian societal perspective. Outcomes were measured in terms of life years (LYs), quality adjusted life years (QALYs), lifetime costs and incremental cost-effectiveness ratio (ICER). The natural progression of the disease was informed by the published literature and previously published modelling exercises. The efficacy of treatments was simulated as reduction of disability progression (EDSS) and relapse rate. Efficacy data were derived from a published network meta-analysis. Unit costs were based on current prices and tariffs, and the published literature. A 3.5% discount rate was applied to costs and outcomes. One-way and probabilistic sensitivity analyses were developed and cost-effectiveness acceptability curves generated.
RESULTS: Peginterferon beta-1a was more effective than the comparators in terms of survival (19.94 vs.19.68-19.81 discounted LYs, respectively), and QALYs (9.07 vs. 8.06 and 8.55 discounted QALY, respectively). In the perspective of the Italian NHS, the ICER was € 11,111/QALY vs. interferon beta-1a 30 µg, € 12,604/QALY vs. interferon beta-1a 22 µg, € 10,580/QALY and € 16,702/QALY vs. interferon beta-1b 250 µg and € 22,023/QALY vs. glatiramer acetate 20 mg. Peginterferon beta-1a dominated interferon beta-1a 44 µg. In the societal perspective, peginterferon beta-1a was dominant due to being more effective and with a lower social cost compared to first-line injectable treatments (interferon beta -1a, interferon beta-1b, glatiramer acetate) for RRMS. The outcomes of the sensitivity analyses confirmed the trend of the base case results.
CONCLUSIONS: Peginterferon beta-1a shows a favourable pharmaco-economic profile for the treatment of RRMS. Even if an official threshold for the cost-effectiveness does not exist in Italy, the ICER values obtained were far below the commonly accepted thresholds (30,000-50,000 €/per QALY gained).
[Article in Italian]
References
Amato MP, Battaglia MA, Caputo D, et al.; Mu. S. I. C. Study Group. The costs of multiple sclerosis: a cross-sectional, multicenter cost-of-illness study in Italy. J Neurol 2002; 249: 152-63; http://dx.doi.org/10.1007/PL00007858
Kobelt G, Berg J, Lindgren P, et al. Costs and quality of life of multiple sclerosis in Italy. Eur J Health Econ. 2006; 7 Suppl 2: S45-54; http://dx.doi.org/10.1007/s10198-006-0385-7
Pugliatti M, Rosati G, Carton H, et al. The epidemiology of multiple sclerosis in Europe. Eur J Neurol 2006; 13: 700-22; http://dx.doi.org/10.1111/j.1468-1331.2006.01342.x
AISM – Associazione Italiana Sclerosi Multipla. Bilancio sociale AISM 2014. Disponibile online su: http://bilanciosociale.aism.it (ultimo accesso novembre 2015)
Olesen J, Gustavsson A, Svensson M, et al.; CDBE2010 study group; European Brain Council. The economic cost of brain disorders in Europe. Eur J Neurol 2012; 19: 155-62; http://dx.doi.org/10.1111/j.1468-1331.2011.03590.x
Naci H, Fleurence R, Birt J, et al. Economic burden of multiple sclerosis: a systematic review of the literature. Pharmacoeconomics 2010; 28: 363-79; http://dx.doi.org/10.2165/11532230-000000000-00000
Ponzio M, Gerzeli S, Brichetto G, et al. Economic impact of multiple sclerosis in Italy: focus on rehabilitation costs. Neurol Sci 2015; 36: 227-34; http://dx.doi.org/10.1007/s10072-014-1925-z
Berto P, Amato MP, Bellantonio P, et al. The direct cost of patients with multiple sclerosis: a survey from Italian MS centres. Neurol Sci 2011; 32: 1035-41; http://dx.doi.org/10.1007/s10072-011-0578-4
Patti F, Amato MP, Trojano M, et al. Multiple sclerosis in Italy: cost-of-illness study. Neurol Sci 2011; 32: 787-94; http://dx.doi.org/10.1007/s10072-011-0499-2
Kobelt G, Berg J, Lindgren P, et al. Costs and quality of life in multiple sclerosis in Europe: method of assessment and analysis. Eur J Health Econ 2006; 7 Suppl 2: S5-13; http://dx.doi.org/10.1007/s10198-006-0365-y
Karampampa K, Gustavsson A, Miltenburger C, et al. Treatment experience, burden and unmet needs (TRIBUNE) in MS study: results from Italy. Mult Scler 2012; 18(2 Suppl): 29-34; http://dx.doi.org/10.1177/1352458512441566c
Steinberg S, Faris R, Chang C, et al. Impact of Adherence to Interferons in the Treatment of Multiple Sclerosis. Clin Drug Investig 2010; 30: 89-100; http://dx.doi.org/10.2165/11533330-000000000-00000
Calabresi PA, Kieseier BC, Arnold DL, et al.; ADVANCE Study Investigators. Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol 2014; 13: 657-65; http://dx.doi.org/10.1016/S1474-4422(14)70068-7
Newsome SD, Sperling B, Liu S, et al. Peginterferon Beta-1a Dosed Every 2 Weeks Maintained Efficacy Over 3 Years in Patients With Relapsing-Remitting Multiple Sclerosis. P1098. 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis. Barcellona, 2015
Fantelli V, van de Vooren K, Garattini L, Budget Impact Analysis: stato dell’arte in letteratura e proposta per una definizione in Italia. QF 2011; 15. Disponibile su: http://www.quadernidifarmacoeconomia.com/archivio-qf/qf15/237-n15-valeco.html (ultimo accesso novembre 2015)
Gani R, Giovannoni G, Bates D, et al. Cost-Effectiveness Analyses of Natalizumab (Tysabri®) Compared with Other Disease-Modifying Therapies for People with Highly Active Relapsing-Remitting Multiple Sclerosis in the UK. Pharmacoeconomics 2008; 26: 617-27; http://dx.doi.org/10.2165/00019053-200826070-00008
National Institute for Clinical Excellence (NICE). Guide to the methods of technology appraisal 2013. Disponibile su: https://www.nice.org.uk/article/pmg9/chapter/foreword (ultimo accesso maggio 2015)
Kurtzke JF. A new scale for evaluating disability in multiple sclerosis. Neurology 1955; 5: 580-3
London Health Science Centre, Ontario, Canada
Weinshenker BG, Bass B, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course. Brain 1989; 112: 1419-28
Weinshenker BG, Bass B, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989; 112: 133-46; http://dx.doi.org/10.1093/brain/112.1.133
Kremenchutzky M, Rice GP, Baskerville J, et al. The natural history of multiple sclerosis: a geographically based study 9: observations on the progressive phase of the disease. Brain 2006; 129(Pt 3): 584-94; http://dx.doi.org/10.1093/brain/awh721
Cottrell DA, Kremenchutzky M, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis. Brain 1999; 122: 625-39
National Institute for Clinical Excellence (NICE). Beta interferon and glatiramer acetate for the treatment of multiple sclerosis. NICE technology appraisal guidance [TA32], 2002. Disponibile su: https://www.nice.org.uk/guidance/TA32
National Institute for Clinical Excellence (NICE). Natalizumab for the treatment of adults with highly active relapsing-remitting multiple sclerosis. NICE technology appraisal guidance [TA127], 2007. Disponibile su: https://www.nice.org.uk/guidance/TA127 (ultimo accesso maggio 2015)
Orme M, Kerrigan J, Tyas D, et al. The effect of disease, functional status, and relapses on the utility of people with multiple sclerosis in the UK. Value Health 2007; 10: 54-60; http://dx.doi.org/10.1111/j.1524-4733.2006.00144.x
Tyas D, Kerrigan J, Russell N, et al. The distribution of the cost of multiple sclerosis in the UK: how do costs vary by illness severity? Value Health 2007; 10: 386-9; http://dx.doi.org/10.1111/j.1524-4733.2007.00192.x
Patzold U, Pocklington PR. Course of multiple sclerosis. First results of a prospective study carried out of 102 MS patients from 1976-1980. Acta Neurol Scand 1982; 65: 248-66; http://dx.doi.org/10.1111/j.1600-0404.1982.tb03084.x
ISTAT. Tavole di mortalità della popolazione generale italiana. Anno 2012. Disponibile su: http://demo.istat.it (ultimo accesso novembre 2015)
Pokorski RJ. Long-term survival experience of patients with multiple sclerosis. J Insur Med 1997; 29: 101-6
Tolley K, Hutchinson M, You X, et al. A Network Meta-Analysis of Efficacy and Evaluation of Safety of Subcutaneous Pegylated Interferon Beta-1a versus Other Injectable Therapies for the Treatment of Relapsing-Remitting Multiple Sclerosis. PLoS One 2015; 10: e0127960; http://dx.doi.org/10.1371/journal.pone.0127960
Lublin FD, Cofield SS, Cutter GR, et al.; CombiRx Investigators. Randomized study combining interferon and glatiramer acetate in multiple sclerosis. Ann Neurol 2013; 73: 327-40; http://dx.doi.org/10.1002/ana.23863
Schwid SR, Panitch HS. Full results of the Evidence of Interferon Dose-Response-European North American Comparative Efficacy (EVIDENCE) study: a multicenter, randomized, assessor-blinded comparison of low-dose weekly versus high-dose, high-frequency interferon beta-1a for relapsing multiple sclerosis. Clinical therapeutics 2007; 29: 2031-48; http://dx.doi.org/10.1016/j.clinthera.2007.09.025
Durelli L, Verdun E, Barbero P, et al.; Independent Comparison of Interferon (INCOMIN) Trial Study Group. Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 2002; 359: 1453-60; http://dx.doi.org/10.1016/S0140-6736(02)08430-1
Cohen JA, Barkhof F, Comi G, et al.; TRANSFORMS Study Group. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010; 362: 402-15; http://dx.doi.org/10.1056/NEJMoa0907839
Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 1996; 39: 285-94; http://dx.doi.org/10.1002/ana.410390304
Calabrese M, Bernardi V, Atzori M, et al. Effect of disease-modifying drugs on cortical lesions and atrophy in relapsing-remitting multiple sclerosis. Multiple sclerosis 2012; 18: 418-24; http://dx.doi.org/10.1177/1352458510394702
Etemadifar M, Janghorbani M, Shaygannejad V. Comparison of Betaferon, Avonex, and Rebif in treatment of relapsing-remitting multiple sclerosis. Acta Neurol Scand 2006; 113: 283-7; http://dx.doi.org/10.1111/j.1600-0404.2006.00585.x
Ebers G; PRISMS (Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomised double-blind placebo-controlled study of interferon (beta)-1a in relapsing/remitting multiple sclerosis. Lancet 1998; 352: 1498-504; http://dx.doi.org/10.1016/S0140-6736(98)03334-0
Mikol DD, Barkhof F, Chang P, et al.; REGARD study group. Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the Rebif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial. Lancet Neurology 2008; 7: 903-14; http://dx.doi.org/10.1016/S1474-4422(08)70200-X
Cadavid D, Wolansky LJ, Skurnick J, et al. Efficacy of treatment of MS with IFNbeta-1b or glatiramer acetate by monthly brain MRI in the BECOME study. Neurology 2009; 72: 1976-83; http://dx.doi.org/10.1212/01.wnl.0000345970.73354.17
O’Connor P, Filippi M, Arnason B, et al; BEYOND Study Group. 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study. Lancet Neurology 2009; 8: 889-97; http://dx.doi.org/10.1016/S1474-4422(09)70226-1
Sibley WA. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology 1995; 45: 1277-85; http://dx.doi.org/10.1212/WNL.45.7.1277
Knobler RL, Greenstein JI, Johnson KP, et al. Systemic recombinant human interferon-beta treatment of relapsing-remitting multiple sclerosis: pilot study analysis and six-year follow-up. J Interferon Res 1993; 13: 333-40; http://dx.doi.org/10.1089/jir.1993.13.333
Wroe SJ. Effects of dose titration on tolerability and efficacy of interferon beta-1b in people with multiple sclerosis. J Int Med Res 2005; 33: 309-18; http://dx.doi.org/10.1177/147323000503300306
Fox RJ, Miller DH, Phillips JT, et al.; CONFIRM Study Investigators. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med 2012; 367: 1087-97; http://dx.doi.org/10.1056/NEJMoa1206328
Johnson KP, Brooks BR, Cohen JA, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology 1995; 45: 1268-76; http://dx.doi.org/10.1212/WNL.45.7.1268
Comi G, Filippi M, Wolinsky JS. European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian Glatiramer Acetate Study Group. Ann Neurol 2001; 49: 290-7; http://dx.doi.org/10.1002/ana.64
Bornstein MB, Miller A, Slagle S, et al. A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. N Engl J Med 1987; 317: 408-14; http://dx.doi.org/10.1056/NEJM198708133170703
Parsons S, Carnes D, Pincus T, et al. Measuring troublesomeness of chronic pain by location. BMC Musculoskelet Disord 2006; 7: 34
National Institute for Clinical Excellence (NICE). Depression in adults: recognition and management. NICE guidelines [CG90], 2009. Disponibile su: http://www.nice.org.uk/guidance/cg90 (ultimo accesso maggio 2015)
National Institute for Clinical Excellence (NICE). Irritable bowel syndrome in adults: diagnosis and management. NICE guidelines [CG61], 2008. Disponibile su: http://www.nice.org.uk/guidance/cg61 (ultimo accesso maggio 2015)
van Hoek AJ, Underwood A, Jit M, et al. The impact of pandemic influenza H1N1 on health-related quality of life: a prospective population-based study. PLoS One 2011; 6: e17030; http://dx.doi.org/10.1371/journal.pone.0017030
Agenzia Italiana del Farmaco. Determina 15 giugno 2015. Riclassificazione del medicinale per uso umano «Plegridy» (peginterferone beta-1a), ai sensi dell’articolo 8, comma 10, della legge 24 dicembre 1993, n. 537 (Determina n. 767/2015). GU Serie Generale n.148 del 29-6-2015
Ministero Della Salute. Decreto 23 dicembre 2003. Regime di rimborsabilità e prezzo di vendita della specialità medicinale «Avonex» - interferone beta 1A autorizzata con procedura centralizzata europea. (Decreto /C/N.257/2003). GU n.11 del 15-1-2004
Agenzia Italiana del Farmaco. Determinazione 8 novembre 2011. Regime di rimborsabilità e prezzo di vendita della specialità medicinale AVONEX (interferone beta 1A) (Determinazione/C n. 2699/2011). GU Serie Generale n.272 del 22-11-2011
Agenzia Italiana del Farmaco. Determinazione 21 luglio 2009. Regime di rimborsabilità e prezzo di vendita del medicinale per uso umano «Rebif» (Determinazione 299/2009) (09A09243). GU n.196 del 25-8-2009 - Suppl. Ordinario n. 154
Agenzia Italiana del Farmaco. Determinazione 14 novembre 2011. Regime di rimborsabilità e prezzo di vendita del medicinale Rebif (interferone beta-1a) (Determinazione/C 2729/2011) (11A15146). GU n.274 del 24-11-2011
Agenzia Italiana del Farmaco. Comunicato. Autorizzazione all’immissione in commercio della specialità medicinale per uso umano «Copaxone». GU Serie Generale n.106 del 9-5-2005
Agenzia Italiana del Farmaco. Determinazione 13 novembre 2007. Regime di rimborsabilità e prezzo di vendita di nuove confezioni del medicinale «Betaferon» (interferone beta 1 b) autorizzate con procedura centralizzata europea dalla Commissione europea (Determinazione/C n. 174/2007). GU n.279 del 30-11-2007 - Suppl. Ordinario n. 250
Ministero Della Sanità. Decreto 3 maggio 2000. Regime di rimborsabilità e prezzo di vendita della specialità medicinale “Betaferon”. (Decreto n. 103/2000). GU n.127 del 2-6-2000
Agenzia Italiana del Farmaco. Determinazione 9 marzo 2009. Regime di rimborsabilità e prezzo di vendita del medicinale «Extavia» (interferone beta - 1b). (Determinazione n. 262/2009). GU n.66 del 20-3-2009
Gruppo Neurologi Sclerosi Multipla della Regione Emilia-Romagna e CReVIF — Centro Regionale Valutazione e Informazione sui Farmaci. Percorso Regionale (Emilia-Romagna) di Diagnosi e Terapia della Sclerosi Multipla. Regione Emilia-Romagna, 2011. Disponibile online su: http://salute.regione.emilia-romagna.it/documentazione/ptr/elaborati/128_sclerosi_multipla.pdf (ultimo accesso novembre 2015)
Percorso Diagnostico Terapeutico Assistenziale Sclerosi Multipla – Regione Lazio. Decreto del Commissario ad Acta 13.11.2014, n. 386
Ministero Della Salute. Decreto 18 ottobre 2012. Remunerazione prestazioni di assistenza ospedaliera per acuti, assistenza ospedaliera di riabilitazione e di lungodegenza post acuzie e di assistenza specialistica ambulatoriale (13A00528). GU Serie Generale n.23 del 28-1-2013 - Suppl. Ordinario n. 8
ISTAT. Indice dei prezzi al consumo per famiglie operai e impiegati. Disponibile su: http://rivaluta.istat.it (ultimo accesso novembre 2015)
Garattini L, Castelnuovo E, Lanzeni D, et al. Durata e costo delle visite in medicina generale: il progetto DYSCO. Farmeconomia e Percorsi terapeutici 2003; 4: 109-14
Fattore G. Proposta di linee guida per la valutazione economica degli interventi sanitari in Italia. PharmacoEconomics Italian Research Articles 2009; 11: 83-93
Lucioni C, Ravasio R. Come valutare i risultati di uno studio farmacoeconomico? PharmacoEconomics – Italian Research Articles 2004; 6: 121-30
Messori A, Santarlasci B, Trippoli S. Controvalore economico del farmaco e beneficio clinico: stato dell’arte della metodologia e applicazione di un algoritmo farmacoeconomico. PharmacoEconomics – Italian Research Articles 2003; 5: 53-67
Jönsson B. Changing health environment: The challenge to demonstrate cost-effectiveness of new compounds. Pharmacoeconomics 2004; 22 (Suppl. 4): S5-S10; http://dx.doi.org/10.2165/00019053-200422004-00003
World Health Organization (WHO). Cost effectiveness and strategic planning (WHO-CHOICE). Disponibile su: http://www.who.int/choice/costs/CER_levels/en/
Hernandez L, Guo S, Kinter E, et al. Cost-effectiveness Analysis of Peginterferon Beta-1a Compared with Other Disease-modifying Therapies in the Treatment of Relapsing-remitting Multiple Sclerosis in the United States. AMCP 2014 Nexus Meeting. Boston, 2014
Hernandez L, Guo S, Toro-Diaz H, et al. Cost-Effectiveness Analysis of Peginterferon Beta-1a in the Treatment of Relapsing-Remitting Multiple Sclerosis in Ireland. Value Health 2015; 18: A756; http://dx.doi.org/10.1016/j.jval.2015.09.2460
Hernandez L, Guo S, Toro-Diaz H, et al. Cost-Effectiveness Analysis of Peginterferon Beta-1a in the Treatment of Relapsing-Remitting Multiple Sclerosis in Scotland. Value Health 2015; 18: A756; http://dx.doi.org/10.1016/j.jval.2015.09.2933
Ivanova JI, Bergman RE, Birnbaum HG, et al. Impact of medication adherence to disease-modifying drugs on severe relapse, and direct and indirect costs among employees with multiple sclerosis in the US. J Med Econ 2012; 15: 601-9; http://dx.doi.org/10.3111/13696998.2012.667027
Paolicelli D, D’Onghia M, Pellegrini F, et al. The impact of neutralizing antibodies on the risk of disease worsening in interferon b–treated relapsing multiple sclerosis: a 5 year post-marketing study. J Neurol 2013; 260: 1562-8; http://dx.doi.org/10.1007/s00415-012-6829-3
Paolicelli D, Iannazzo S, Santoni L, et al. The Cost of Patients With Relapsing-Remitting Multiple Sclerosis Who Develop Neutralising Antibodies While Treated With Interferon Beta. ISPOR. Milano, 2015
Lee AW. Review of mixed treatment comparisons in published systematic reviews shows marked increase since 2009. J Clin Epidemiol 2014; 67: 138-43; http://dx.doi.org/10.1016/j.jclinepi.2013.07.014
Jansen JP, Fleurence R, Devine B, et al. Interpreting indirect treatment comparisons and network meta-analysis for health-care decision making: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 1. Value Health 2011; 14: 417-28; http://dx.doi.org/10.1016/j.jval.2011.04.002
Zhang X, Hay JW, Niu X. Cost Effectiveness of Fingolimod, Teriflunomide, Dimethyl Fumarate and Intramuscular Interferon-b1a in Relapsing-Remitting Multiple Sclerosis. CNS Drugs 2015; 29: 71-81; http://dx.doi.org/10.1007/s40263-014-0207-x
Iannazzo S, Santoni L, Saleri C, et al. Budget impact analysis for peginterferon beta-1a in relapsing remitting multiple sclerosis in Italy. Farmeconomia. Health Economics and Therapeutic Pathways 2016; 17(Suppl 2): 37-48; http://dx.doi.org/10.7175/fe.v17i2S.1231
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