Assessment of the innovative quality of agomelatine through the Innovation Assessment Algorithm

Assessment of the innovative quality of agomelatine through the Innovation Assessment Algorithm

Authors

  • Liliana Civalleri SIFEIT – Società Italiana per Studi di Economia ed Etica sul Farmaco e sugli Interventi Terapeutici [Italian Association for Research on the Economics and Ethics of Medications and Therapeutic Procedures], Rome
  • Sabrina Licata SIFEIT – Società Italiana per Studi di Economia ed Etica sul Farmaco e sugli Interventi Terapeutici [Italian Association for Research on the Economics and Ethics of Medications and Therapeutic Procedures], Rome

DOI:

https://doi.org/10.7175/fe.v13i3.279

Keywords:

Agomelatine, IAA, Innovation, Efficacy, Effectiveness

Abstract

Aim: the aim of this study was to assess the innovative quality of a medicine based on agomelatine, authorized by the European Commission through a centralized procedure on 19th February 2009 and distributed in Italy under the brands Valdoxan® and Thymanax®.

Methodology: the degree of innovation of agomelatine was determined through the Innovation Assessment Algorithm (IAA), which considers the innovative quality of a medicine as a combination of multiple properties. The algorithm may be represented as a decision tree, with each branch corresponding to a property connected with innovation and having a fixed numerical value. The sum of these values establishes the degree of innovation of the medicine. The IAA is articulated in two phases: the first assesses the efficacy of the drug based on the clinical trials presented in support of the registration application (IAA-efficacy); the second reconsiders the degree of innovation on the basis of the efficacy and safety data resulting from clinical practice once the drug has been placed on the market (IAA-effectiveness).

Results and conclusions: the score obtained for agomelatine was 592.73 in the efficacy phase and 291.3 in the effectiveness phase. The total score for the two phases was 884, which is equivalent to a good degree of innovation for the molecule

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Published

2012-09-21

How to Cite

Civalleri, L., & Licata, S. (2012). Assessment of the innovative quality of agomelatine through the Innovation Assessment Algorithm. Farmeconomia. Health Economics and Therapeutic Pathways, 13(3), 141–152. https://doi.org/10.7175/fe.v13i3.279

Issue

Vol. 13 No. 3 (2012)

Section

Original research

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