Invasive fungal infections in hematology: epidemiology and risk factors

Authors

  • Matteo Bassetti Clinica di Malattie Infettive, A.O.U. Santa Maria della Misericordia, Udine
  • Morena Caira Istituto di Ematologia, Università Cattolica del Sacro Cuore, Roma
  • Agostinho Carvalho Sezione di Microbiologia, Dipartimento di Medicina Sperimentale e Scienze Biomediche, Università degli Studi di Perugia

DOI:

https://doi.org/10.7175/rhc.v3i1S.428

Keywords:

Invasive fungal disease, Epidemiology, Hematology

Abstract

Recent Italian and International epidemiological data show that invasive fungal infections (IFI), particularly aspergillosis, are still a crucial issue for patients with acute myeloid leukemia. However, in the last years the epidemiology is changing, and in order to determine the real risk of a patient and in order to improve preventive, diagnostic and therapeutic measures, it’s important to identify all the factors (e.g. age, performance status, prophylaxis) that play a role in the development of IFI. Immunogenetics may potentially contribute to improve diagnosis providing new therapeutic tools, but results are limited by sample size and absence of thorough functional characterization moreover lack of replication limits translation of data to the clinical practice. Regarding candidemia an Italian study showed that the overall incidence remained unchanged between 2008 and 2010 but with an increase in the number of C. albicans aand C. glabrata infections.

Downloads

Published

2012-10-29

Issue

Vol. 3 No. 1S (2012)

Section

Supplement

License

Authors who publish with this journal agree to the following terms:
  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. The Publication Agreement can be downloaded here, and should be signed by the Authors and sent to the Publisher when the article has been accepted for publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  4. Authors are permitted to post their work online after publication (the article must link to publisher version, in html format)