Long lasting octreotide LAR therapy in non functioning pancreatic neuroendocrine carcinoma

Long lasting octreotide LAR therapy in non functioning pancreatic neuroendocrine carcinoma

Authors

  • Ivan Lolli UO Oncologia Medica, Policlinico Bari
  • Antonio Logroscino UO Oncologia Medica, Policlinico Bari
  • Simona Vallarelli UO Oncologia Medica, Policlinico Bari
  • Maria A. Monteduro UO Radiodiagnostica Ospedaliera 1, Policlinico Bari
  • Antonella Gentile UO Oncologia Medica, Policlinico Bari
  • Giuseppe Troccoli UO Oncologia Medica, Policlinico Bari

DOI:

https://doi.org/10.7175/cmi.v4i1S.1067

Keywords:

Non functioning metastatic endocrine tumour, Histological test, Somatostatin analogues

Abstract

Non functioning endocrine pancreatic tumors (NF-PETs) have absent or low hormone secretion without symptoms and constitue ~60% of PETs. At diagnosis more than 50% of patients have liver metastases and almost 40% are not candidates for radical surgery because of either locally advanced disease or unresectable metastases. We described the case of a 47-year-old woman with a pancreatic carcinoma with secondarism in the liver not suitable for radical surgery. Histological test of liver metastases showed positivity for endocrine well-differentiated non functioning carcinoma expressing receptors for somatostatin with very low proliferation index (Ki67 < 2%). After this diagnosis she started a specific treatment with octreotide analogues which achieved durable stabilization of the disease.

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Published

2015-10-13

Issue

Vol. 4 No. 1S (2010)

Section

Case report

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