A case of serious bleeding

A case of serious bleeding

Authors

  • Irene Ricca SS Lungodegenza, Presidio Ospedaliero Cottolengo, Torino
  • Marisa Coggiola SS Lungodegenza, Presidio Ospedaliero Cottolengo, Torino
  • Silvia Destefanis SS Lungodegenza, Presidio Ospedaliero Cottolengo, Torino
  • Claudio Pascale SC Medicina Interna, Presidio Ospedaliero Cottolengo, Torino

DOI:

https://doi.org/10.7175/cmi.v5i2S.1106

Keywords:

Acquired haemophilia, Coagulation factor VIII, Activated partial thromboplastin time

Abstract

Acquired haemophilia A (AHA) is a rare disorder with a high mortality rate. It occurs due to autoantibodies against coagulation factor VIII (FVIII) which neutralise its procoagulant function resulting in severe bleeding. This disease may be associated with autoimmune diseases, malignancies, infections or medications and occurs most commonly in the elderly. Diagnosis is based on the isolated prolongation of aPTT which does not normalise after the addition of normal plasma along with reduced FVIII levels. Treatment involves eradication of antibodies and maintaining effective haemostasis during bleeding. We report a case of a 76-year-old patient with a history of haemorrhage with severe anaemia. The article describes difficulties and complexities of clinical and therapeutic management of the patient.

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Published

2015-10-13

Issue

Vol. 5 No. 2S (2011)

Section

Case report

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