Nilotinib early switch efficacy in non-optimal responder CML patient after first line imatinib treatment

Nilotinib early switch efficacy in non-optimal responder CML patient after first line imatinib treatment

Authors

  • Ferdinando Porretto UO Oncoematologia e TMO, Dip. Oncologico La Maddalena, Palermo

DOI:

https://doi.org/10.7175/cmi.v5i6S.1133

Keywords:

Sub-optimal responder, Nilotinib, Imatinib, BCR-ABL mutations

Abstract

We report a case of a patient with chronic myeloid leukemia in chronic phase who was treated with Imatinib as first line therapy. He showed a suboptimal response by 2006 ELN criteria after six months, for this reason we performed a mutational analysis that showed the mutation F486S. Due to this finding we made an early switch to Nilotinib (Nil); patients started Nil at 300 bid mg/day obtaining at six month a complete cytogenetic response (CCyR) and a MMolR (RQ-PCR ratio BCR-ABL1/ABL1%IS: 0.05). The patient is now on 24 months Nil treatment showing a RQ-PCR ratio BCR-ABL1/ABL1%IS: 0.004.

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Published

2015-10-13

Issue

Vol. 5 No. 6S (2011)

Section

Case report

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