Dysthyroidism and heart failure: from clinical case to pathophysiology

Dysthyroidism and heart failure: from clinical case to pathophysiology

Authors

  • Stefano Giordanetti SOC Medicina Interna, Ospedale degli Infermi, Biella

DOI:

https://doi.org/10.7175/cmi.v4i3S.1152

Keywords:

Dysthyroidism, Heart failure, Phospholamban, Lusitropism, Diastolic dysfunction

Abstract

Dysthyroidism affects cardiovascular function in many ways and can cause heart failure. The physiopathological mechanisms underlying the development of heart failure involve both direct intranuclear transcriptional effects of thyroid hormones and specific haemodynamic consequences of vascular modifications induced by dysthyroidism. Phospholamban regulatory action on diastolic ventricular function appears to play a pivotal role in mediating both direct T3 action and adrenal effects on myocardial contractility, possibly explaining the way dysthyroidism mimics sympathoadrenergic alterations on cardiovascular function. Therapeutical approach to cardiovascular disorders in dysthyroidism should focus on both thyroid hormones dysregulation and sympathoadrenergic activity, to attempt a reversal of the associated derangements.

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Published

2015-10-13

Issue

Vol. 4 No. 3S (2010)

Section

Case report

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