Penis cancer: a case report

Penis cancer: a case report

Authors

  • Gregorio Sampalmieri Polo ospedaliero S. Spirito, Villa Betania – Roma
  • Antonello Moretti Polo ospedaliero S. Spirito, Villa Betania – Roma
  • Luca De Pascale Polo ospedaliero S. Spirito, Villa Betania – Roma
  • Matteo Sampalmieri Polo ospedaliero S. Spirito, Villa Betania – Roma

DOI:

https://doi.org/10.7175/cmi.v8i2.906

Keywords:

Penis cancer, Squamous-cell carcinoma, Partial penectomy surgery

Abstract

Penis cancer appears as a small lesion that extends gradually to affect the whole of the glans and the shaft of the penis. Its peak incidence is in men aged 40 to 70 years. The most frequent malignant penis tumour is squamous cell carcinoma, which occurrence is probably favoured by smegma accumulation, HPV16 and 18 infection, smoke, and balanitis xerotica obliterans. Here we discuss the case of a 74-year-old man with sovrapubic pain and swelling. Physical examination reveals swollen glans with purulent secretions and oedema. The final diagnosis of squamous cell carcinoma is established by means of RMN and biopsy. Partial penectomy surgery follows. Histopathological examination shows poorly differentiated endophytic infiltrative growth. The tumour infiltrates corpus spongiosum, corpora cavernosa, and urethra. The proximal uretheral stump is free from infiltration (pT3).

References

Ornellas P, Ornellas AA, Chinello C, et al. Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis. Int Braz J Urol 2012; 38: 739-49; http://dx.doi.org/10.1590/1677-553820133806739

Dillner J, Meijer CJLM, von Krogh G, et al. Epidemiology of human papillomavirus infection. Scand J Urol Nephrol Sup 2000; 34: 194-200; http://dx.doi.org/10.1080/00365590050509922

Jemal A, Simard EP, Dorell C, et al. Annual Report to the Nation on the status of cancer, 1975-2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst 2013; 105: 175-201; doi: 10.1093/jnci/djs491; http://dx.doi.org/10.1093/jnci/djs491

Crook JM, Haie-Meder C, Demanes DJ, et al. American Brachytherapy Society-Groupe Européen de Curiethérapie-European Society of Therapeutic Radiation Oncology (ABS-GEC-ESTRO) consensus statement for penile brachytherapy. Brachytherapy 2013; 12: 191-8; doi: 10.1016/j.brachy.2013.01.167; http://dx.doi.org/10.1016/j.brachy.2013.01.167

Noronha V, Patil V, Ostwal V, et al. Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer. Urol Ann 2012; 4: 150-3; doi: 10.4103/0974-7796.102659; http://dx.doi.org/10.4103/0974-7796.102659

McDouglas WS. Advances in the treatment of carcinoma of the penis. Urology 2005; 66(5 suppl): 114-7; http://dx.doi.org/10.1016/j.urology.2005.06.007

Syeds S, Eng TY, Thomas CR, et al. Current issues in the management of advanced squamous cell carcinoma of the penis. Urol Oncol 2003; 21: 431-8; http://dx.doi.org/10.1016/S1078-1439(03)00058-9

Kroon BK, Horenblas S, Nieweg OE. Contemporary management of penile squamous cell carcinoma. J Surg Oncol 2005; 89: 43-50; http://dx.doi.org/10.1002/jso.20170

Pizzocaro G, Algaba F, Horenblas S, et al; European Association of Urology (EAU) Guidelines Group on Penile Cancer. EAU penile cancer guidelines 2009. Eur Urol 2010; 57: 1002-12; http://dx.doi.org/10.1016/j.eururo.2010.01.039

Sanchez-Ortiz RF, Pettaway CA. The role of lymphadenectomy in penile cancer. Urol Oncol 2004; 22: 236-44; discussion 244-5; http://dx.doi.org/10.1016/j.urolonc.2004.04.031

Singh I, Khaitan A. Current trends in the management of carcinoma penis-a review. Int Urol Nephrol 203; 35: 215-25

Brady KL, Mercurio MG, Brown MD. Malignant tumors of the penis. Dermatol Surg 2013; 39: 527-47; doi: 10.1111/dsu.12029; http://dx.doi.org/10.1111/dsu.12029

Downloads

Published

2014-06-26

Issue

Vol. 8 No. 2 (2014)

Section

Case report

License

Authors who publish with this journal agree to the following terms:
    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial 4.0 Licence that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. The Publication Agreement can be downloaded here, and should be signed by the Authors and sent to the Publisher when the article has been accepted for publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
    4. Authors are permitted to post their work online after publication (the article must link to publisher version, in html format)